NOTICIAS

Resveratrol may increase a beneficial hormone

01/01/2011

Researchers at the University of Texas discovered that the health benefits of resveratrol may be due to the stimulation of the fat hormone adiponectin.

Resveratrol is a naturally occurring polyphenol found in a variety of foods - especially in grape skin and red wine - that has been linked with health benefits. However, how resveratrol exerts its beneficial health effects remains largely unknown. Now researchers at the University of Texas discovered that the health benefits of resveratrol may be due to the stimulation of the fat hormone adiponectin. Adiponectin is exclusively secreted from fat tissue into the bloodstream and is the most abundant adipokine (*) produced by the human adipose tissue. What is unique about this fat cell-derived hormone is that its circulating concentration is inversely proportional to adiposity: the more obese a person, the lower the adiponectin level.
Adiponectin is a protein hormone that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism and it enhances insulin-sensitivity. This it is linked to insulin resistance, metabolic syndrome, non-alcoholic fatty liver disease, inflammation and several types of cancers. Low adiponectin concentrations strongly predict the development of type 2 diabetes and cardio-vascular disease.
Consequently, in the decade since its discovery, adiponectin has generated immense interest as a potential therapeutic target for the metabolic syndrome and diabetes. Through medication and lifestyle alteration, the low level of adiponectin in obesity can be increased.
If resveratrol can increase the adiponectin level, more of the proposed health effects could be explained. Resveratrol is a stilbenoid, a type of polyphenol, and a phytoalexin produced naturally by several plants when under attack by pathogens such as bacteria or fungi.
Resveratrol and its effects have been the topic of interest in numerous animal and human studies and it has been shown that it has potent antioxidant and anti-inflammatory effects, promotes vascular endothelial function, enhances lipid metabolism, and has anticancer activity. It has also been demonstrated that it exerts anti-aging effects in animals.
The mechanisms of resveratrol's apparent effects on life extension are not fully understood, but they appear to mimic several of the biochemical effects of calorie restriction. Some studies indicate that resveratrol improves the functioning of the mitochondria.
Further research is needed to quantify the dose-response relationship between resveratrol intake and adiponectin activation and its effect on prevention and therapy of metabolic diseases.
Wang A, Liu M, Liu X, et al. Up-regulation of adiponectin by resveratrol: the essential roles of the Akt/FOXO1 and AMP-activated protein kinasesignaling pathways and DsbA-L. J BiolChem 2011;286:60-66
(*)The adipokines are cytokines (cell-to-cell signalling proteins) secreted by adipose tissue

 

Comentarios

Esta noticia no tiene ningún comentario

Escriba aquí su comentario:



Recargar Imagen

Código:

Fivin Wine in moderation