01/01/2011
A pooled analysis of six ongoing large-scale cohort studies in Japan estimated the quantitative contribution of alcohol consumption to all-cause and major causes of mortality in the Japanese population
The analysis included the 309 082 subjects with 35 801 deaths during a follow-up period ranging from 7 to 18 years. A J- or U-shaped association was found for the risk of total and major causes of mortality in men, and the risk of total and heart disease mortality in women. Compared to non-drinkers, there was a significantly lower risk of total mortality at an alcohol consumption level of <69 g/day, cancer mortality at <46 g/day, heart disease mortality at <69 g/day and cerebro-vascular disease mortality at <46 g/day in men, and for total mortality at <23 g/day in women. At a higher consumption, the mortality risk increased linearly with rising dose of alcoholic beverages among drinkers.
The scientists concluded that keeping the intake of alcoholic beverages below 46 g/day in men and 23 g/day in women appears to minimise the mortality risk in the Japanese population.